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diets contain two to three times more satu- This dietary shift, combined with an increas- rated fat than polyunsaturated fat.19,20 Our ingly sedentary lifestyle, is a major cause of ancestors ate wild game that was low in total many common diseasesheart disease, osteo- fat (only about 4% fat) but provided rich porosis, tooth decay, high blood pressure, and amounts of beneficial omega-3 fatty acids diabetes

Currently, subcutaneous hormone injections are most commonly used for the treatment of keloids and HS, but this treatment has a clinical recurrence rate of 9%50%, and multiple injections may lead to hypopigmentation and skin atrophy (Ogawa, 2022)

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Cytoskeletal regulation of epithelial barrier function during inflammation